Both the infarction area and ischemia-induced neuronal apoptosis deteriorated by EphA4-OE could be redeemed by NF-κB inhibitor PDTC (P < 0.01), and there were no significant differences between MCAO + EphA4-OE + PDTC group and MCAO + Lenti Control group in infarction size as well as ischemia-induced neuronal apoptosis (Fig. 4 A2, A4, A5, A6, B2, B4, B5, B6). This evidence concerns the gene EPHA4 and ischemia.