IL1B and alkaline phosphatase measurement: Wedrolactone (Wed) is a caspase-11 inhibitor that can inhibit the IκB kinase (IKK) complex and inhibit the expression of caspase-11, which effectively inhibits the caspase-11-dependent pyroptosis signaling pathway and reduces mature IL-1β and GSDMD-N levels to protect against AP and AP-induced AKI [61,62].