Research on anti-cancer treatments also focused heavily on the PI3K/Akt pathway, where PI3K stands for phosphoinositide 3-kinase and Akt stands for protein kinase B. This prototype survival pathway also receives external signals from a large number of membrane receptors (such as EGFR), and it plays a crucial role in the survival of cells and the formation of new blood vessels in a variety of different ways. Here, AKT1 is linked to cancer.