The most important findings of this study were the incidence of PE following UE trauma was 0.64%, UE trauma patients should be actively followed for PE if they are active smokers, have DM, HT, hypothyroidism, malignancy, coagulation disease (JAK2 gene mutation), or a CVC, and anticoagulant prophylaxis may be beneficial for UE trauma patients with these underlying conditions. The gene discussed is JAK2; the disease is hypothyroidism.