PPP1R1B and Huntington disease: Further investigation of concordantly dysregulated genes between BCL11BKO and HD models confirmed deficits in DA-DARPP32 signaling, cAMP-PKA-calcium signaling axis, synaptic signaling, oxidative phosphorylation, and mitochondrial function predominantly in MSNs and to a lesser extent in cortical neurons (Figure 4D, Table S4).