In addition, proinflammatory cytokines such as interleukin-1β, tumor necrosis factor-alpha, and interleukin-6 in patients with diabetes, induce the phenotype switching of smooth muscle cells (SMCs) from contractile to synthetic phenotype.4, 5, 6, 7 Despite the use of drug eluting stents, patients with diabetes still have an increased risk of in-stent restenosis and late stent thrombosis.8 This evidence concerns the gene TNF and diabetes mellitus.