ERBB2 and cancer: SFKs are known as proto-oncogenes, meaning that over-activation of these proteins can contribute to cancer progression and metastasis in various types of cancers, such as colorectal carcinoma, different subtypes of breast cancer (triple negative, HER2+, basal, etc.), lung adenocarcinoma, and leukaemia, among others (Belsches-Jablonski et al., 2001; Aligayer et al., 2002; Li, 2007; Zhang et al., 2007; Tryfonopoulos et al., 2011; Chougule et al., 2016; Ichihara et al., 2017).