Indeed, Src upregulation (by activating ArfGAP1 and repressing LATS) significantly increases YAP/TAZ activity, as well as modulates the expression of YAP/TAZ-regulated genes, such as CTGF, TGFB1, EGFR, SOX2 (SRY-Box Transcription Factor 2), BIRC5 (Survivin), CTNNB1 (β-Catenin), and FGF1/2 (Fibroblast Growth Factor 1 and 2), among others, promoting tumour growth and metastasis (Zhao et al., 2008; Muramatsu et al., 2010; Frum et al., 2018; Lu et al., 2018; Qin et al., 2018; Ortega et al., 2021; Lu et al., 2022). Here, SOX2 is linked to neoplasm.