CSK and cancer: Indeed, many cancer cells express low levels of CSK and elevated activation of SFKs, leading to more invasive cell phenotypes (Howell and Cooper, 1994; Han et al., 1996; Obergfell et al., 2002; Pema et al., 2005; Wheeler et al., 2009; Li et al., 2016; Wullkopf et al., 2018; Ding et al., 2021).