The NLRP3−/− as well as the NLRP6−/− mice have been shown to have a higher incidence of intestinal tumors in the AOM-DSS model due to their inability to produce mature forms of IL-18 and IL-1β (Allen et al., 2010; Zaki et al., 2010b; Hu et al., 2010; Chen et al., 2011). The gene discussed is NLRP6; the disease is infectious otitis media.