The exact mechanism underlying increased IEC proliferation in NLR-deficient mice remains largely unknown, but NLRP6−/− mice have shown increased expression of proto-oncogenic genes such as Mycl1 involved in the Wnt pathway in the AOM-DSS model (Normand et al., 2011), highlighting the possibility of similar mechanisms involved in the tumorigenesis in other knock-out models. Here, NLRP6 is linked to infectious otitis media.