IKBKG and Chronic colitis: NEMO is involved in the activation of the canonical NF-κB signaling pathway, and a mouse model with IEC-specific deletion of NEMO shows spontaneous development of severe chronic colitis, characterized by epithelial ulceration, infiltration of immune cells, increased expression of pro-inflammatory mediators, impaired expression of antimicrobial peptides, and translocation of bacteria into the bowel wall (Nenci et al., 2007).