MyD88−/− mice show no proliferation in IECs after AOM-DSS treatment (Schiechl et al., 2011), however, MyD88−/− mice show an overall increased susceptibility to AOM-DSS induced intestinal tumors due to an upregulation of Wnt signaling associated genes, angiogenesis and DNA repair. Here, MYD88 is linked to intestinal neoplasm.