Zeng et al. (2018) found that sEV-miR-25-3p was upregulated in CRC metastatic sEVs and promoted CRC vascular permeability and angiogenesis by targeting KLF2 and KLF4 to regulate the expression of VEGFR5, ZO-2, occludin, and Claudin4 in endothelial cells. Shang et al. (2020b) revealed that overexpression of miR-183-5p, which targets FOXO1, increased proliferation, invasion, and angiogenesis of CRC cells and may serve as a potential biomarker for CRC. This evidence concerns the gene KLF2 and colorectal carcinoma.