lncRNA PCAT1 was highly expressed in CRC primary cell lines and their sEVs, and knockdown of PCAT1 resulted in upregulation of Netrin-1 and CD146 expression, downregulation of miR-329-3p expression, increased proliferation and migration capacity of T84 cells, and enhanced F-actin signaling after undergoing co-culture experiments, promoting CRLM (Fang et al., 2022). Here, PCAT1 is linked to colorectal carcinoma.