Lu et al. (2022) have demonstrated that Fn can promote CRC metastasis by upregulating long non-coding RNA (lncRNA) EVADR expression, making EVADR a modular scaffold for Y-box binding protein 1 (YBX1), which in turn directly enhances the translation of epithelial-mesenchymal transition (EMT)-related factors. This evidence concerns the gene FN1 and colorectal carcinoma.