This involved Guanine nucleotide exchange factors (GEFs) for the regulation of Rho GTPase activity such as the dedicator of cytokinesis proteins DOCK4, DOCK6, and DOCK10, suggesting a central role of the DOCK protein family which was already shown for DOCK2 in a genome‐wide association study (GWAS) in patients with severe cases of COVID‐19 (Namkoong et al, 2022). This evidence concerns the gene DOCK4 and COVID-19.