Overlap of essential E‐boxes for four cancer cell lines revealed only three (1%) common E‐boxes (Fig. 3C): chr1_BS1363_CACAATG with neighbor genes MECR and PTPRU, chr11_BS79_CGCGTG localized near RPLP2 and PIDD1, and chr18_BS691_CATGTG adjacent to RBFA and TXNL4A. The gene discussed is PIDD1; the disease is cancer.