The promyelocytic leukemia (PML) gene was first described in the early 1990s at the point of chromosomal translocation t (15, 17), where it was found to encode an oncogenic chimeric protein emerging from the fusion of PML and the retinoic acid receptor alpha (RAR‐α) in patients with acute promyelocytic leukemia (APL). This evidence concerns the gene PML and acute promyelocytic leukemia.