PIEZO1 and early-onset autosomal dominant Alzheimer disease: Interestingly, PIEZO1 overexpression has been observed to occur in neurodegenerative disorders including Alzheimer's disease or multiple sclerosis.[96, 97] In this study PIEZO1 displayed a significant ≈2.4‐fold increase in expression (control 1.22 vs treated 2.89; p = 0.0304) relative to cells cultured under static control conditions (Figure 5B).