Previous studies have demonstrated that increased adipose tissue and circulating levels of BMP4 can promote the browning of SAT and, thus, counteract obesity by reducing body weight and ameliorating insulin sensitivity [10, 11], However, while BMP-4 levels are increased in obesity [3, 12], beige/brown adipose cell markers are reduced. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.