However, Konstantopoulos et al. found that cell migration and cancer dissemination are facilitated by increased ECF viscosity.163 The crosstalk between ECF and cells induces the actin-related protein 2/3 (ARP2/3)-complex-dependent actin network, which triggers Na+/H+ exchanger 1 (NHE1) polarization. This evidence concerns the gene ACTR2 and cancer.