RHOA and cancer: In response to mechanical stimulation, ECM-induced remodeling activates integrins to facilitate the RhoA/ROCK signaling pathway in cellular mechanotransduction and osteogenetic differentiation of mesenchymal stem cells.340 Stiff ECM-mediated integrin-induced directional migration through RhoA/ROCK signaling cascades provides new insights into inhibiting cancer metastasis.341 A study on mechanical stress-associated cardiac valve remodeling revealed that the mechanical stress-induced valvular fibrosis through RhoC signaling but was independent of RhoA signaling.342