Cancer cell migration is initiated by CAFs, which secret protease to remodel the ECM and break through the ECM barrier.650 CAFs commonly express high-level α-SMA, which may be activated by TGFβ.651 CAFs can also be activated by mechanical cues via MRTF-SRF and YAP-TEAD signaling pathways.652 Together, ECM stiffness, FSS, HP, and TF are mechanical properties that trigger cancer cell behaviors.653. This evidence concerns the gene HP and cancer.