Interestingly, fibroblast can also be activated by CD44/RhoA/YAP-mediated mechanics-induced pulmonary fibrosis.311 Recent research demonstrated that ANKED42, a novel circRNA-ankyrin repeat domain 42, sponges miR324-5p to activate AJUBA expression, inhibiting the interaction between phosphorylated YAP and LATS1/2, thus resulting in YAP translocation to the nucleus. The gene discussed is RHOA; the disease is pulmonary fibrosis.