TGFB1 and Myocardial fibrosis: In myocardial fibrosis, Selenbp1 knockdown enhances fibroblast activation and deters fibroblast transformation to matrix-degrading form.568 Mechanical cues activate TGFβ1, which is latent in ECM, subsequently activating fibroblasts.569 The activated fibroblasts are transformed to injury-related fibroblasts subtype, promoting ECM secretion.