MTHFR and alcohol dependence: Considering that the recent meta-analysis revealed no association of MTHFR 677T/T and alcohol dependence, the effect of MTHFR genotype on drinking behavior might be relatively limited.66 In addition, the reduced blood FA levels in subjects with MTHFR 677 T/T genotype in the present study are in accordance with the previous report,67 underscoring the requirements for more folate intake in those with MTHFR 677 T/T genotype than in those with other genotypes.