Whereas the multivariable Cox-regression analyses of MFS indicated that the prognostic factors were liver transplantation (HR 2.337, 95% CI 1.004-5.443, P = 0.049), positive of AST (HR 5.993, 95% CI 1.352-26.561, P = 0.018), larger tumor diameter (HR 2.645, 95% CI 1.284-5.446, P = 0.008), grade MVI-M1(HR 2.763, 95% CI 1.281-5.963, P = 0.010), macrovascular invasion (HR 2.798, 95% CI 1.008-7.766, P = 0.048), higher Ki67 percentage (HR20.337, 95% CI 1.590-260.160, P = 0.021) and γ-OHPdG higher levels (HR 1.008, 95% CI 1.003-1.014, P = 0.002). The gene discussed is MKI67; the disease is neoplasm.