In particular, corpus callosum agenesis, polymicrogyria and focal cortical dysplasias are described in MED12L,8MED13L,29,30MED256,31 and CDK8-related disorders.11 This evidence raises the hypothesis of possible disruption of neurodevelopmental mechanisms often associated with neurodegenerative processes in several MEDopathies. This evidence concerns the gene CDK8 and polymicrogyria.