INS and type 2 diabetes mellitus: In addition, the association of smoking behavior change with CVD risk and mortality was not changed by T2DM status, however, it is noteworthy that the absolute risk reduction from smoking cessation would be greater in severe T2DM patients (e.g., long duration of T2DM and insulin use), given a higher risk of CVD incidence [35] and mortality [36] as the duration of T2DM increased.