Using generalised linear models, higher levels of interferon regulating factor 5 (IRF5), solute carrier family 22 member 2 (SLC22A2) and S100 calcium binding protein A12 (S100A12) were identified in SLE patients compared to healthy matched controls; in our data the S100A12 pathway was increased in our C1B subcluster. This evidence concerns the gene S100A12 and systemic lupus erythematosus.