Among those proteins in our study which associated with the presence of AD, IL-17C is expressed in AD lesions as described above, while MCP-4 is an eosinophil-specific chemotactic factor related to AD [30], uPA activity is linked to transepidermal water loss in dry AD skin [31] and CD6 is a T cell surface protein found to be overexpressed in AD skin [32]. Here, PLAU is linked to Alzheimer disease.