Pre-incubation with JQ1 + resulted in a decrease in recruitment of NF-κB p65 to the κB binding site on the IL-6 (Fig. 4A and B) and IL-8 (Fig. 4C and D) promotor regions to near basal levels in control and PAH HPMEC. Here, NFKB1 is linked to pulmonary arterial hypertension.