The BET mimic JQ1 suppressed TNFα-induced IL-6 and CXCL8/IL-8 release and mRNA expression to a similar extent in control and PAH HPMECs and HPASMCs reflecting a similar degree of suppression of TNFα-induced NF-κB p65 and BRD4 recruitment to the IL-6 and CXCL8/IL-8 promoters. Here, CXCL8 is linked to pulmonary arterial hypertension.