BRD4 and pulmonary arterial hypertension: In the Sugen/hypoxia rat model, BRD4 inhibition using JQ1 or siBRD4 in vivo reversed established PAH and decreased proliferation, increased apoptosis and restored mitochondrial membrane potential in PAH-PASMCs, suggesting that BRD4 upregulation may be pathologically associated with PAH [18].