However, RVX208, which preferentially binds to the second bromodomain in BRD2 and BRD4, reversed the inflammatory and proliferative phenotypes of PAH HPMECs and HPASMCs and reversed monocrotaline- and Sugen5416 + hypoxia-induced in vivo models of PAH [26]. This evidence concerns the gene BRD4 and pulmonary arterial hypertension.