Moreover, anti-invasive and anti-migratory action of naringenin were clarified in 12-O-tetradecanoylphorbol-13-acetate (TPA)-activated hepatoma cells by the downregulation of protein kinase C (PKC), epidermal growth factor (EGF), mitogen activated protein kinase (MAPK) and phosphoinositide 3 – kinase L protein kinase B (PI3K/Akt) signaling pathways, and NF-κB, activator protein 1 (AP-1) and matrix metalloproteinase (MMP9) activities [54]. This evidence concerns the gene NFKB1 and hepatocellular carcinoma.