PTEN and posterior cortical atrophy: To ascertain whether METTL1 upregulation in PCa was a direct consequence of low or loss of PTEN expression, we analysed Mettl1 mRNA and protein levels in prostate tissues from wild-type (WT) mice and Probasine-Cre x Ptenflox/flox mice (hereafter Pten-KO), with conditionally have deleted Pten in the prostate epithelium.