Immunohistochemical analysis further revealed that Mettl1 expression was higher in murine PCa and was highly expressed in luminal cells, which are the most common epithelial cell type and are generally accepted as the preferred cell of origin for human prostate cancer [49] (Fig. 2L; Supplementary Fig. S2F, S2G). This evidence concerns the gene METTL1 and Familial prostate cancer.