To further clarify whether METTL1 expression was regulated under the AR pathway, we measured the mRNA levels of METTL1 after dihydrotestosterone (DHT) treatment in the androgen-sensitive PCa cell line, LNCaP, and found no changes (Supplementary Fig. S2B), suggesting that METTL1 expression is not regulated by AR activity. Here, AR is linked to posterior cortical atrophy.