To determine whether the observed anti-tumour effect upon Mettl1 deletion in mice was due to increased intratumoural infiltration of cytotoxic CD8+ T cells, we examined the effect of systemic elimination of CD8+ T cells in Pten-KO/Mettl1 + / + and Pten-KO/Mettl1fl/fl mice treated with anti-CD8α antibodies. This evidence concerns the gene METTL1 and neoplasm.