PTEN and neoplasm: Mettl1 heterozygous deletion (Pten-KO/Mettl1 +/-) and Mettl1 conditional deletion in the prostatic epithelium of Pten-KO mice (Pten-KO/Mettl1flox/flox) resulted in a significant decrease in the tumour volume of the ventral and anterior lobes, which were consistently larger in Pten-KO/Mettl1 + / + mice (Fig. 7F; Supplementary Fig. S9F).