Based on these observations and the capability of METTL1-deficient cells to elicit a cytotoxic immune response characterised by the induction of M1-like macrophage polarisation, as well as enhanced proliferation and migration of CD8+ T cells in vitro (Fig. 7A-D, Supplementary Fig. S8A-E), our subsequent investigation focused on analysing the composition of macrophages and CD8+ T cells in Mettl1-deficient prostate tumours. The gene discussed is METTL1; the disease is prostate neoplasm.