The well-known driver genes we identified from BRCA of breast cancer include AKT1, CDKN1B, ESR1, GATA3, MAP3K13, TP53, etc. Well-known driver genes identified from pancreatic cancer included AKT2, DAXX, FAT4, KRAS, etc. LUAD included ARAF, EED, GPC, TP53, etc. The rest of the cancers were also analyzed and can be seen in Table S3. The gene discussed is ESR1; the disease is cancer.