SNAI1 and melanoma: To investigate whether this was also the case in melanoma, we used a similar approach and injected a VIVO-morpholino (VI-MO) that targets a splicing site in the Snai1 mRNA (Snail1-MO) [54] into the tail vein of C57BL/6 mice with established BrafV600E-5555 lung metastases (Fig. 6a).