TF and malignant colon neoplasm: In this regard, we noted that an intersection between the set of predicted transcription factors for SIRT4 through TFSEARCH software [21] and the fact of direct binding of forkhead family transcription factor (TF) FOXQ1 at SIRT4 promoter according to a published ChIP-seq (chromatin immunoprecipitation coupled with massively parallel DNA sequencing) analysis in the LoVo human colon cancer cells [22] suggested that FOXQ1 could be a putative candidate TF for transcription regulation of SIRT4.