SQSTM1 and frontotemporal dementia: Globular, juxtanuclear p62-positive cytoplasmic inclusion bodies were present in cortical brain sections of all FTD cases examined (Fig. 6A) and were similar to those seen in mVCP mice (Fig. 5A), suggesting a generalised disruption in protein homeostasis in FTD patients; no p62 immunostaining was observed in brain sections from healthy controls.