TARDBP and amyotrophic lateral sclerosis: Similar to ALS and MSP, cytoplasmic mislocalisation of TDP-43 is a pathological characteristic of FTD, with mislocalised TDP-43 present in the brain of approximately 50% of FTD cases, and brain pathology often indistinguishable from that seen in FTD patients with a mutation in the TARDBP gene itself [9, 42].