For example AML cells depend on myo-inositol import through SLC5A3 due to silencing of ISYNA1, an enzyme involved in myo-inositol biosynthesis,52 or ovarian cancer cells depend on phosphate exporter SLC53A1 (XPR1) due to overexpression of phosphate importer SLC34A2. 53In principle, the PARADISO assay design would also be applicable in these cases, expanding its potential to additional opportunities beyond SLC-SLC genetic interactions. The gene discussed is ISYNA1; the disease is acute myeloid leukemia.