IGF1R is a growth factor receptor involved in the progression of multiple cancer types through its activation of several downstream oncogenic pathways.70-73 While under basal conditions, this IGF1R mutation does not change cell growth rates (Figure S4G), when cells’ access to IGF1R ligands was reduced by either decreasing FBS or replacing it with charcoal-stripped serum,74 we observe a growth advantage in the mutant cells (Figure 5E). The gene discussed is IGF1R; the disease is cancer.