In CRC cell lines, we assessed the capacity of ECG and EGCG dimers to: i) inhibit EGF-stimulated MMP-2/9 expression/activity and cell invasion, ii) inhibit EGF-stimulated signaling cascades that promote MMP-2/9 transcription, i.e. NF-κB (IKKα, p65), ERK1/2 and Akt; iii) inhibit O2.-/H2O2 production through NOX modulation (expression/activity). The gene discussed is AKT1; the disease is colorectal carcinoma.