Considering, the NOX-dependent redox regulation of EGFR activation in tumor progression [21,22,40], and previous evidence showing that PCA modulate oncogenic signals, i.e. ERK1/2, Akt, NF-κB, in part by mitigating NOX-mediated transient O2.-/H2O2 increases [21,41,42], the present study investigated if ECG and EGCG dimers could inhibit CRC cell invasion through a EGFR/NOX1-dependent MMP-2/9 downregulation. This evidence concerns the gene EGFR and colorectal carcinoma.