Compared to ccRCC (Fig. 2) BAP1, CHEK2, IRS1, PBRM1, SETD2, TERT, and VHL in evRCC patients, PAX8, CDKN2A, CDKN2B, FANCC, FGFR4, PIK3C, PTPRS, SMARCB1, TERT in pRCC ASXL2, BRCA1, CDH1, CDKN2A, CDKN2B, CDKN2C, DNMT1, and EP300 mutations in chRCC patients were mainly found. Here, PBRM1 is linked to chromophobe renal cell carcinoma.