The data showed that the DFS of the ccRCC patients with SETD2 (Fig. 5A), BAP1 (Fig. 5B), PBRM1 (Fig. 5C), NPM1 (Fig. 6A), ERBB2 (Fig. 6B), CSFR1 (Fig. 6C), and ERBB3 (Fig. 6D) gene mutations were significant shorter than that of wild type patients over time. Here, NPM1 is linked to nonpapillary renal cell carcinoma.