Like other reports, BAP1, PBRM1, SETD2, and VHL are always the most frequently mutated genes.31, 32, 33 Among these gene mutations, VHL play a critical role in ccRCC because at least one allele loss of VHL gene was identified in over 90% ccRCC patients.8 This evidence concerns the gene PBRM1 and nonpapillary renal cell carcinoma.