Compared to ccRCC (Fig. 2) BAP1, CHEK2, IRS1, PBRM1, SETD2, TERT, and VHL in evRCC patients, PAX8, CDKN2A, CDKN2B, FANCC, FGFR4, PIK3C, PTPRS, SMARCB1, TERT in pRCC ASXL2, BRCA1, CDH1, CDKN2A, CDKN2B, CDKN2C, DNMT1, and EP300 mutations in chRCC patients were mainly found. The gene discussed is PAX8; the disease is chromophobe renal cell carcinoma.