Interestingly, the Asian population with AD does not present elevated levels of TSLP (SMD = 0.71, 95% CI − 0.07 to 1.49, p = 0.076), which could be partly related to the fact that the Asian AD phenotype presents a blended phenotype between that of European-American patients with AD and those with psoriasis; furthermore, this population shows increased epidermal hyperplasia, greater TH17/TH22 and lower TH1 skewing, and comparable TH2 activation [37, 38]. This evidence concerns the gene TSLP and Alzheimer disease.