Demethylation is mediated by some specific demethylases (termed “erasers”), such as FTO, ALKBH3/5, etc.[8c] YTHDF2, the first identified m6A‐binding protein, is upregulated in certain malignant tumors, including gastric cancer, colorectal cancer, etc., and can promote their development.[8a] Functionally, YTHDF2 controls protein expressions by regulating the translation and stability of specific mRNAs.[8, 9] However, the role and modification of YTHDF2 in HCC are still not fully understood. The gene discussed is YTHDF2; the disease is colorectal cancer.