Heat shock protein 90 beta (HSP90β) promotes the progression of hepatocellular carcinoma (HCC) by suppressing STIP1 homology and U‐box‐containing protein 1 (STUB1)‐induced YTHDF2 ubiquitination, which may inaugurate a novel intervention strategy for the treatment of HCC. Here, YTHDF2 is linked to hepatocellular carcinoma.