IGHE and Autoimmunity: The authors proposed that CU exacerbation occurs as the host’s immune and inflammatory response to SARS-CoV-2 vaccines rather than a hypersensitivity reaction since no features or autoimmunity (such as the presence of autoimmune thyroid disorders, anti-TPO positivity, low IgE, and eosinopenia) nor atopy (presence of atopic disorders, high IgE, and prick test positivity) were associated with CU exacerbation in this study.