The research by O’Toole et al. [37] and Marques et al. [36] showed that, in an infection with RHDV2, there is a marked upregulation of the three acute-phase cytokines IL-6, IL-1β, IL-1, IFN-γ, IL-8, and TNF-α in the spleen [37]. This evidence concerns the gene CXCL8 and infection.