Since alternative splicing of RIOK3 occurs during RVFV infection and the splicing shift appears concurrently with activation of the noncanonical NFκB pathway, we then investigated whether RIOK3′s alternatively spliced isoform, RIOK3 X2, has a direct effect on innate immune responses during RVFV MP12 infection. Here, NFKB1 is linked to infection.