During viral infection, the immune response begins when viral RNA is detected in the cytosol by RIG-I-like receptors (RLRs), specifically RIG-1, which have two amino-terminal caspase activation and recruitment domains (CARDs); these domains interact with mitochondrial antiviral signaling protein, which are proteins of the mitochondrial outer membrane, and its activation is essential for initiating the production of type I interferons (IFN) and pro-inflammatory cytokines [57]. Here, IFNA1 is linked to viral infectious disease.