The associations of plasma PCSK9 with the need for dialysis, ventilation, or catecholamine treatment were calculated for the SIRS/sepsis patients (1) without liver cirrhosis and COVID-19, (2) patients with liver cirrhosis after the exclusion of patients with COVID-19, and (3) patients with COVID-19 after the exclusion of patients with liver cirrhosis (Table 2). The gene discussed is PCSK9; the disease is COVID-19.