To determine if there was a correlation among the expression levels of the four Yamanaka factors in different cancers, a Spearman correlation coefficient was calculated for the expression of OCT4, KLF4, SOX2, MYC, in a pan-cancer analysis that included all cancer types (Figure 5G) as well as a targeted breast cancers analysis (Figure 5H). The gene discussed is SOX2; the disease is breast cancer.