RAP1B and infection: However, Rap1b activation seems to occur throughout the entire process of HSV-1 infection, while in HEV infection, it is restricted to early infection events (i.e., virus attachment or penetration process), which may result from the intrinsic properties of the experimental models, as cell lines only support early entry HEV with inefficient replication [26,56], while for HSV-1 and many other viruses, cell lines allow for efficient replication and cell-to-cell transmission [28,29,40,57].