The Rho GTPase family proteins, the ras homolog family member A (RhoA), CDC42, and RAC1, are widely defined as effectors involved in cytoskeleton regulation [32], and numerous studies have found that the Rho GTPase family is involved in targeting the cytoskeleton in the process of virus infection, such as dengue virus (DENV) [33], African swine fever virus (ASFV) [34], pseudorabies virus (PRV) [35], etc. [36]. Here, CDC42 is linked to viral infectious disease.