RAP1B and viral infectious disease: Nonetheless, treating cells with phosphorylation and prenylation-interrelated mutants before virus infection significantly improved and promoted the activation of Rap1b and viral infection in a dose-dependent manner, indicating that competition between phosphorylation and prenylation modification in the PBR of Rap1b may be the main factors limiting the activation of Rap1b during HSV-1 infection rather than GTP loading from the limitation of GEFs [22].