For example, patients with APL achieve complete remission via progressive differentiation of leukemic cells, as ATRA dissociates corepressors from promyelocytic leukemia protein (PML)-RARα oncoprotein, opens the chromatin structure, and recruits a coactivator that converts PML-RARα from a repressor to an activator [5]. Here, RARA is linked to acute promyelocytic leukemia.