The reported significant CD4+ and CD8+ T-cell response induced by the S1-RBD subunit (Ag1) and the S1 and S2 subunits of the S protein CD8+ T-cell epitopes (Ag2) after the first and second vaccine dose was similar to COVID-19 vaccinated healthy individuals reported in previous studies [39,40]. This evidence concerns the gene CD8A and COVID-19.