PDCD1LG2 and infection: Infected MIO-M1 cells also showed significantly increased expression of transcripts encoding two immunomodulatory cell surface molecules, programmed death-ligand (PD-L)1 (p < 0.0001) and PD-L2 (p < 0.0001), but expression of the immunomodulatory cytokine, IL-10, was unchanged following infection (Figure 2D).