Further, we observed regulation of both IFNA1 and IFNB1 modulated several pathways, such as the RIG-I-like receptor signalling pathway, Hepatitis B, lipid and atherosclerosis, Toll-like receptor signalling pathway, Influenza A, Coronavirus disease—COVID-19, NOD-like receptor signalling pathway, and cytosolic DNA-sensing pathway, whereas regulation of IFNB1 modulated Yersinia infection and the TNF signalling pathway. The gene discussed is TNF; the disease is Yersinia infectious disease.