Herein, FGF-21 analogs (NA-FGF) that were bio-fermented and purified from strain DNZY1 with longer-lasting hypoglycemic effects were used as the diabetes treatment drug, and N-2-HACC/CMCS MPs were employed as the carrier to construct the NA-FGF-N-2-HACC/CMCS MPs. Here, FGF21 is linked to diabetes mellitus.