Rubiyunnanins H has been reported for its cytotoxic activity in in vitro cultures of cancer cell lines, as well as its ability to inhibit nitric oxide production in the LPS model and IFN-Υ-induced RAW 264.7 murine macrophages, and to inhibit NF-κB and TNF-α activation [32]. The gene discussed is NFKB1; the disease is cancer.