IFNG and neoplasm: While IFN-γ can act in the TME to restrict tumor growth, induce apoptotic pathways, and stimulate other immune cells to increase anti-tumor activity, IFN-γ can also exhibit pro-tumorigenic functions at sustained or low doses, and low IFN-γ levels are correlated with poor prognosis in non-small cell lung cancer (NSCLC) [47,48,49].