Known SNPs in KDR Exon 11 (c.1416 A > T, p.Q472H), PIK3CA Exon 7 (c.1173 A > G, p.I391M), STK11 Intron 3 (c.465-51 T > C) and TP53 Exon 4 (c.215 C > G, p.P72R) and a cancer driver mutation in TP53 Exon 7 (c.715_720del, p.N239 _S240del) were detected in organoid cells in correspondence with the primary tumor. The gene discussed is PIK3CA; the disease is neoplasm.