RUNX2 and breast cancer: Notable examples include runt-related transcription factors (RUNXs) in several cancer cell types [108] (RUNX1: acute myeloid leukemia, gastric cancer, hepatocellular carcinoma, and breast cancer [109,110,111,112]; RUNX2: osteosarcoma, bone metastasis of prostate cancer, breast cancer, and so on [113,114,115]; and RUNX3: epithelial ovarian cancer and basal cell carcinoma) [116], N-Myc (MYCN) in neuroblastoma [117], and C-Myc (MYC), which contributes to the cause of at least 40% of human tumors [118].